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All drugs may cause side effectsHowevermany people have no side effects or only have minor side effectsCall your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

This antibiotic treats only bacterial infectionsIt will not work for viral infectionssuch as common coldfluUsing any antibiotic when it is not needed can cause it to not work for future infections.

This antibiotic treats only bacterial infectionsIt will not work for viral infectionssuch as common coldfluUsing any antibiotic when it is not needed can cause it to not work for future infections.

CommentsAdditional drug/s should be given with this drug to treat patients with susceptible strains of tuberculosisMalabsorption syndrome may occur in patients who adhere to treatment but fail to appropriately respondand may be present in patients with concurrent HIV infectionTherapeutic drug monitoring should be considered in patients with malabsorption syndromeThe duration of treatment should be based on clinical responseincluding permanent bacteriological conversion and maximal clinical improvementThe American Academy of PediatricsAAPrecommends once a day treatment with isoniazidrifampinand pyrazinamide for 2 months in patients with meningitis caused by M tuberculosisand once a day treatment with isoniazid and rifampin for 9 to 12 months in patients with meningitis caused by Mycoplasma bovis.

Ethionamide is generally bacteriostatic at the doses that can be achieved in humansSince its action is somewhat similar to isoniazid'sand the latter appears to have AUC/MIC as the primary pharmacodynamically linked variableperhaps that also is true of ethionamide.

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ethionamide is a prodrug 19 which is activated by the enzyme etha, a mono-oxygenase in mycobacterium tuberculosis , and then binds nad to form an adduct which inhibits inha in the same way as isoniazid.

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