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There are no data from the effect of sevelamer on fertility in humansStudies in animals have shown that sevelamer did not impair fertility in male or female rats at exposures at a human equivalent dose 2 times the maximum clinical trial dose of 13 g/daybased on a comparison of relative body surface area.

In all of the studiesthe main measure of effectiveness was the change in blood phosphate levels between the start and the end of treatment.

May decrease GI absorption of antiarrhythmicfat soluble vitaminsfolic acidand antiseizure medicationstake medications 1 hour before or 3 hours after sevelamer dose.

Switching from the hydrochloride salt to carbonateUse the same dosehowever further titration may be necessary to achieve desired phosphorus levels.

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